Ontology highlight
ABSTRACT:
SUBMITTER: Ekpenyong AE
PROVIDER: S-EPMC5470826 | biostudies-other | 2017 Jun
REPOSITORIES: biostudies-other
Science advances 20170614 6
The transition of neutrophils from a resting state to a primed state is an essential requirement for their function as competent immune cells. This transition can be caused not only by chemical signals but also by mechanical perturbation. After cessation of either, these cells gradually revert to a quiescent state over 40 to 120 min. We use two biophysical tools, an optical stretcher and a novel microcirculation mimetic, to effect physiologically relevant mechanical deformations of single nonadh ...[more]