Ontology highlight
ABSTRACT:
SUBMITTER: Anderson MP
PROVIDER: S-EPMC547889 | biostudies-other | 2005 Feb
REPOSITORIES: biostudies-other
Anderson Matthew P MP Mochizuki Takatoshi T Xie Jinghui J Fischler Walter W Manger Jules P JP Talley Edmund M EM Scammell Thomas E TE Tonegawa Susumu S
Proceedings of the National Academy of Sciences of the United States of America 20050126 5
It has long been suspected that sensory signal transmission is inhibited in the mammalian brain during sleep. We hypothesized that Cav3.1 T-type Ca2+ channel currents inhibit thalamic sensory transmission to promote sleep. We found that T-type Ca2+ channel activation caused prolonged inhibition (>9 s) of action-potential firing in thalamic projection neurons of WT but not Cav3.1 knockout mice. Inhibition occurred with synaptic transmission blocked and required an increase of intracellular Ca2+. ...[more]