Maternal folate deficiency causes inhibition of mTOR signaling, down-regulation of placental amino acid transporters and fetal growth restriction in mice.
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ABSTRACT:
SUBMITTER: Rosario FJ
PROVIDER: S-EPMC5479823 | biostudies-other | 2017 Jun
REPOSITORIES: biostudies-other
Publications
Maternal folate deficiency causes inhibition of mTOR signaling, down-regulation of placental amino acid transporters and fetal growth restriction in mice.
Rosario Fredrick J FJ Nathanielsz Peter W PW Powell Theresa L TL Jansson Thomas T
Scientific reports 20170621 1
Maternal folate deficiency is linked to restricted fetal growth, however the underlying mechanisms remain to be established. Here we tested the hypothesis that mTOR functions as a folate sensor in vivo in mice and that maternal folate deficiency inhibits placental mTOR signaling and amino acid transporter activity and causes fetal growth restriction. Folate deficient mice had lower serum folate (-60%). In late pregnancy, fetal weight in the folate deficient group was decreased (-17%, p < 0.05), ...[more]
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