Ontology highlight
ABSTRACT:
SUBMITTER: Bernitt E
PROVIDER: S-EPMC5481797 | biostudies-other | 2017 Jun
REPOSITORIES: biostudies-other
Bernitt Erik E Döbereiner Hans-Günther HG Gov Nir S NS Yochelis Arik A
Nature communications 20170619
During macropinocytosis, cells remodel their morphologies for the uptake of extracellular matter. This endocytotic mechanism relies on the collapse and closure of precursory structures, which are propagating actin-based, ring-shaped vertical undulations at the dorsal (top) cell membrane, a.k.a. circular dorsal ruffles (CDRs). As such, CDRs are essential to a range of vital and pathogenic processes alike. Here we show, based on both experimental data and theoretical analysis, that CDRs are propag ...[more]