Ontology highlight
ABSTRACT:
SUBMITTER: Sun L
PROVIDER: S-EPMC5497799 | biostudies-other | 2017 Jul
REPOSITORIES: biostudies-other
Sun Lin L Kong Yinlong Y Cao Manqing M Zhou Hongyuan H Li Huikai H Cui Yunlong Y Fang Feng F Zhang Wei W Li Jiafeng J Zhu Xiaolin X Li Qiang Q Song Tianqiang T Zhang Ti T
Cancer science 20170520 7
Metastasis is a serious risk that may occur during the treatment of hepatocellular carcinoma (HCC), preventing many patients from being surgical candidates and contributing to poor prognosis. Hypoxia has been proved an important factor of metastasis through the epithelial-mesenchymal transition (EMT) pathway. Acetyl-CoA synthase 2 (ACSS2) provides an acetyl group for the acetylation of hypoxia-inducible factor (HIF)-2α, and this epigenetic modification affects the activity of HIF-2α and the subs ...[more]