Ontology highlight
ABSTRACT:
SUBMITTER: Xiao B
PROVIDER: S-EPMC5498804 | biostudies-other | 2017 Jul
REPOSITORIES: biostudies-other
Xiao Bo B Xu Zhigang Z Viennois Emilie E Zhang Yuchen Y Zhang Zhan Z Zhang Mingzhen M Han Moon Kwon MK Kang Yuejun Y Merlin Didier D
Molecular therapy : the journal of the American Society of Gene Therapy 20170128 7
Overcoming adverse effects and selectively delivering drug to target cells are two major challenges in the treatment of ulcerative colitis (UC). Lysine-proline-valine (KPV), a naturally occurring tripeptide, has been shown to attenuate the inflammatory responses of colonic cells. Here, we loaded KPV into hyaluronic acid (HA)-functionalized polymeric nanoparticles (NPs). The resultant HA-KPV-NPs had a desirable particle size (∼272.3 nm) and a slightly negative zeta potential (∼-5.3 mV). These NPs ...[more]