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Antioxidant and vitamin E transport genes and risk of high-grade prostate cancer and prostate cancer recurrence.

ABSTRACT: Observational studies suggest an inverse association between vitamin E and risk of prostate cancer, particularly aggressive tumors. However, three large randomized controlled trials have reported conflicting results. Thus, we examined circulating vitamin E and vitamin E-related genes in relation to risk of high-grade prostate cancer and prostate cancer recurrence among men initially diagnosed with clinically organ-confined disease.We measured circulating α- and γ-tocopherol and genotyped 30 SNPs in SOD1, SOD2, SOD3, TTPA, and SEC14L2 among 573 men with organ-confined prostate cancer who underwent radical prostatectomy. We examined associations between circulating vitamin E, genotypes, and risk of high-grade prostate cancer (Gleason grade ≥ 8 or 7 with primary score ≥ 4; n = 117) using logistic regression, and risk of recurrence (56 events; 3.7 years median follow-up) using Cox proportional hazards regression.Circulating γ-tocopherol was associated with an increased risk of high-grade prostate cancer (Q4 v. Q1 odds ratio [OR] = 1.87; 95% confidence intervals [CI]: 0.97-3.58; P trend =0.02). The less common allele in SOD3 rs699473 was associated with an increased risk of high-grade disease (T > C: OR = 1.40, 95% CI: 1.04-1.89). Two independent SNPs in SOD1 were inversely associated with prostate cancer recurrence in additive models (rs17884057 hazard ratio [HR] = 0.49, 95%CI: 0.25-0.96; rs9967983 HR = 0.62, 95% CI: 0.40-0.95).Among men with clinically organ-confined prostate cancer, genetic variation in SOD may be associated with risk of high-grade disease at diagnosis and disease recurrence. Circulating γ-tocopherol levels may also be associated with an increased risk of high-grade disease at diagnosis.

SUBMITTER: Bauer SR

PROVIDER: S-EPMC5501162 | biostudies-other | 2013 Dec

REPOSITORIES: biostudies-other

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Antioxidant and vitamin E transport genes and risk of high-grade prostate cancer and prostate cancer recurrence.

Bauer Scott R SR Richman Erin L EL Sosa Eduardo E Weinberg Vivian V Song Xiaoling X Witte John S JS Carroll Peter R PR Chan June M JM

The Prostate 20130829 16

<h4>Background</h4>Observational studies suggest an inverse association between vitamin E and risk of prostate cancer, particularly aggressive tumors. However, three large randomized controlled trials have reported conflicting results. Thus, we examined circulating vitamin E and vitamin E-related genes in relation to risk of high-grade prostate cancer and prostate cancer recurrence among men initially diagnosed with clinically organ-confined disease.<h4>Methods</h4>We measured circulating α- and ...[more]

PMID: 24038157

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Antioxidant and vitamin E transport genes and risk of high-grade prostate cancer and prostate cancer recurrence.

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Antioxidant and vitamin E transport genes and risk of high-grade prostate cancer and prostate cancer recurrence.

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