Ontology highlight
ABSTRACT:
SUBMITTER: Zong G
PROVIDER: S-EPMC5502735 | biostudies-other | 2017 Jun
REPOSITORIES: biostudies-other
Bioorganic & medicinal chemistry letters 20170421 12
Ipomoeassin F is a plant-derived macrocyclic glycolipid with single-digit nanomolar IC<sub>50</sub> values against cancer cell growth. In previous structure-activity relationship studies, we have demonstrated that certain modifications around the fucoside moiety did not cause significant cytotoxicity loss. To further elucidate the effect of the fucoside moiety on the biological activity, we describe here the design and synthesis of several fucose-truncated monosaccharide analogues of ipomoeassin ...[more]