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A Novel MgO-CaO-SiO₂ System for Fabricating Bone Scaffolds with Improved Overall Performance.


ABSTRACT: Although forsterite (Mg₂SiO₄) possesses good biocompatibility and suitable mechanical properties, the insufficient bioactivity and degradability hinders its further application. In this study, a novel MgO-CaO-SiO₂ system was developed by adding wollastonite (CaSiO₃) into Mg₂SiO₄ to fabricate bone scaffolds via selective laser sintering (SLS). The apatite-forming ability and degradability of the scaffolds were enhanced because the degradation of CaSiO₃ could form silanol groups, which could offer nucleation sites for apatite. Meanwhile, the mechanical properties of the scaffolds grew with increasing CaSiO₃ to 20 wt %. It was explained that the liquid phase of CaSiO₃ promoted the densification during sintering due to its low melting point. With the further increase in CaSiO₃, the mechanical properties decreased due to the formation of the continuous filling phase. Furthermore, the scaffolds possessed a well-interconnected porous structure and exhibited an ability to support cell adhesion and proliferation.

SUBMITTER: Sun H 

PROVIDER: S-EPMC5502980 | biostudies-other | 2016 Apr

REPOSITORIES: biostudies-other

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