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Factors Associated with the Duration of Moderate-to-Severe Diarrhea among Children in Rural Western Kenya Enrolled in the Global Enteric Multicenter Study, 2008-2012.


ABSTRACT: Diarrheal disease is a leading cause of death among young children worldwide. As rates of acute diarrhea (AD; 1-6 days duration) have decreased, persistent diarrhea (PD; > 14 days duration) accounts for a greater proportion of the diarrheal disease burden. We describe factors associated with the duration of moderate-to-severe diarrhea in Kenyan children < 5 years old enrolled in the Global Enteric Multicenter Study. We found 587 (58%) children experienced AD, 360 (35%) had prolonged acute diarrhea (ProAD; 7-13 days duration), and 73 (7%) had PD. We constructed a Cox proportional hazards model to identify factors associated with diarrheal duration. Risk factors independently associated with longer diarrheal duration included infection with Cryptosporidium (hazard ratio [HR]: 0.868, P = 0.035), using an unimproved drinking water source (HR: 0.87, P = 0.035), and being stunted at enrollment (HR: 0.026, P < 0.0001). Diarrheal illness of extended duration appears to be multifactorial; given its association with adverse health and development outcomes, effective strategies should be implemented to reduce the duration and severity of diarrheal illness. Effective treatments for Cryptosporidium should be identified, interventions to improve drinking water are imperative, and nutrition should be improved through exclusive breastfeeding in infants ? 6 months and appropriate continued feeding practices for ill children.

SUBMITTER: Schilling KA 

PROVIDER: S-EPMC5508904 | biostudies-other | 2017 Jul

REPOSITORIES: biostudies-other

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Factors Associated with the Duration of Moderate-to-Severe Diarrhea among Children in Rural Western Kenya Enrolled in the Global Enteric Multicenter Study, 2008-2012.

Schilling Katharine A KA   Omore Richard R   Derado Gordana G   Ayers Tracy T   Ochieng John B JB   Farag Tamer H TH   Nasrin Dilruba D   Panchalingam Sandra S   Nataro James P JP   Kotloff Karen L KL   Levine Myron M MM   Oundo Joseph J   Parsons Michelle B MB   Bopp Cheryl C   Laserson Kayla K   Stauber Christine E CE   Rothenberg Richard R   Breiman Robert F RF   O'Reilly Ciara E CE   Mintz Eric D ED  

The American journal of tropical medicine and hygiene 20170701 1


Diarrheal disease is a leading cause of death among young children worldwide. As rates of acute diarrhea (AD; 1-6 days duration) have decreased, persistent diarrhea (PD; > 14 days duration) accounts for a greater proportion of the diarrheal disease burden. We describe factors associated with the duration of moderate-to-severe diarrhea in Kenyan children < 5 years old enrolled in the Global Enteric Multicenter Study. We found 587 (58%) children experienced AD, 360 (35%) had prolonged acute diarrh  ...[more]

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