Ontology highlight
ABSTRACT:
SUBMITTER: Jaillet C
PROVIDER: S-EPMC5509684 | biostudies-other | 2017 Jul
REPOSITORIES: biostudies-other
Jaillet Cyprien C Morelle Willy W Slomianny Marie-Christine MC Paget Vincent V Tarlet Georges G Buard Valérie V Selbonne Sonia S Caffin Fanny F Rannou Emilie E Martinez Pierre P François Agnès A Foulquier François F Allain Fabrice F Milliat Fabien F Guipaud Olivier O
Scientific reports 20170713 1
As it is altered by ionizing radiation, the vascular network is considered as a prime target in limiting normal tissue damage and improving tumor control in radiation therapy. Irradiation activates endothelial cells which then participate in the recruitment of circulating cells, especially by overexpressing cell adhesion molecules, but also by other as yet unknown mechanisms. Since protein glycosylation is an important determinant of cell adhesion, we hypothesized that radiation could alter the ...[more]