Lipid Droplets Can Spontaneously Bud Off from a Symmetric Bilayer.
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ABSTRACT:
SUBMITTER: Deslandes F
PROVIDER: S-EPMC5510809 | biostudies-other | 2017 Jul
REPOSITORIES: biostudies-other
Publications
Lipid Droplets Can Spontaneously Bud Off from a Symmetric Bilayer.
Deslandes François F Thiam Abdou Rachid AR Forêt Lionel L
Biophysical journal 20170621 1
Lipid droplets (LDs) are cytosolic organelles that protrude from the endoplasmic reticulum membrane under energy-rich conditions. How an LD buds off from the endoplasmic reticulum bilayer is still elusive. By using a continuous media description, we computed the morphology of a lipid droplet embedded in between two identical monolayers of a bilayer. We found that beyond a critical volume, the droplet morphology abruptly transits from a symmetrical elongated lens to a spherical protrusion. This b ...[more]
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