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Keratins Are Going Nuclear.


ABSTRACT: Previously thought to reside exclusively in the cytoplasm, the cytoskeletal protein keratin 17 (K17) has been recently identified inside the nucleus of tumor epithelial cells with a direct impact on cell proliferation and gene expression. We comment on fundamental questions raised by this new finding and the associated significance.

SUBMITTER: Hobbs RP 

PROVIDER: S-EPMC5511689 | biostudies-other | 2016 Aug

REPOSITORIES: biostudies-other

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Keratins Are Going Nuclear.

Hobbs Ryan P RP   Jacob Justin T JT   Coulombe Pierre A PA  

Developmental cell 20160801 3


Previously thought to reside exclusively in the cytoplasm, the cytoskeletal protein keratin 17 (K17) has been recently identified inside the nucleus of tumor epithelial cells with a direct impact on cell proliferation and gene expression. We comment on fundamental questions raised by this new finding and the associated significance. ...[more]

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