Ontology highlight
ABSTRACT:
SUBMITTER: Muhich ML
PROVIDER: S-EPMC55121 | biostudies-other | 1990 Dec
REPOSITORIES: biostudies-other
Muhich M L ML Iida C T CT Horikoshi M M Roeder R G RG Parker C S CS
Proceedings of the National Academy of Sciences of the United States of America 19901201 23
Proper initiation of transcription by RNA polymerase II requires the TATA-consensus-binding transcription factor TFIID. A cDNA clone encoding the Drosophila TFIID protein has been isolated and characterized. The deduced amino acid sequence reveals an open reading frame of 353 residues. The carboxyl-terminal 180 amino acids are approximately 80% identical to yeast TFIID and 88% identical to human TFIID. The amino-terminal portions of the yeast and Drosophila TFIID proteins lack appreciable homolo ...[more]