An antifreeze glycopeptide gene from the antarctic cod Notothenia coriiceps neglecta encodes a polyprotein of high peptide copy number.
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ABSTRACT:
SUBMITTER: Hsiao KC
PROVIDER: S-EPMC55145 | biostudies-other | 1990 Dec
REPOSITORIES: biostudies-other
Publications
An antifreeze glycopeptide gene from the antarctic cod Notothenia coriiceps neglecta encodes a polyprotein of high peptide copy number.
Hsiao K C KC Cheng C H CH Fernandes I E IE Detrich H W HW DeVries A L AL
Proceedings of the National Academy of Sciences of the United States of America 19901201 23
The antarctic fish Notothenia coriiceps neglecta synthesizes eight antifreeze glycopeptides (AFGP 1-8; Mr 2600-34,000) to avoid freezing in its ice-laden freezing habitat. We report here the sequence of one of its AFGP genes. The structural gene contains 46 tandemly repeated segments, each encoding one AFGP peptide plus a 3-amino acid spacer. Most of the repeats (44/46) code for peptides of AFGP 8; the remaining 2 code for peptides of AFGP 7. At least 2 of the 3 amino acids in the spacers could ...[more]
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