Ontology highlight
ABSTRACT:
SUBMITTER: Rinaldi L
PROVIDER: S-EPMC5520900 | biostudies-other | 2017 Jun
REPOSITORIES: biostudies-other
Rinaldi Laura L Sepe Maria M Delle Donne Rossella R Conte Kristel K Arcella Antonietta A Borzacchiello Domenica D Amente Stefano S De Vita Fernanda F Porpora Monia M Garbi Corrado C Oliva Maria A MA Procaccini Claudio C Faicchia Deriggio D Matarese Giuseppe G Zito Marino Federica F Rocco Gaetano G Pignatiello Sara S Franco Renato R Insabato Luigi L Majello Barbara B Feliciello Antonio A
Cell death & disease 20170601 6
Mitochondria are the powerhouses of energy production and the sites where metabolic pathway and survival signals integrate and focus, promoting adaptive responses to hormone stimulation and nutrient availability. Increasing evidence suggests that mitochondrial bioenergetics, metabolism and signaling are linked to tumorigenesis. AKAP1 scaffolding protein integrates cAMP and src signaling on mitochondria, regulating organelle biogenesis, oxidative metabolism and cell survival. Here, we provide evi ...[more]