Ontology highlight
ABSTRACT:
SUBMITTER: Raven A
PROVIDER: S-EPMC5522613 | biostudies-other | 2017 Jul
REPOSITORIES: biostudies-other
Raven Alexander A Lu Wei-Yu WY Man Tak Yung TY Ferreira-Gonzalez Sofia S O'Duibhir Eoghan E Dwyer Benjamin J BJ Thomson John P JP Meehan Richard R RR Bogorad Roman R Koteliansky Victor V Kotelevtsev Yuri Y Ffrench-Constant Charles C Boulter Luke L Forbes Stuart J SJ
Nature 20170712 7663
After liver injury, regeneration occurs through self-replication of hepatocytes. In severe liver injury, hepatocyte proliferation is impaired-a feature of human chronic liver disease. It is unclear whether other liver cell types can regenerate hepatocytes. Here we use two independent systems to impair hepatocyte proliferation during liver injury to evaluate the contribution of non-hepatocytes to parenchymal regeneration. First, loss of β1-integrin in hepatocytes with liver injury triggered a duc ...[more]