Unknown

Dataset Information

0

Endothelial Dysfunction in Children With Obstructive Sleep Apnea Is Associated With Elevated Lipoprotein-Associated Phospholipase A2 Plasma Activity Levels.


ABSTRACT: Obstructive sleep apnea (OSA) is a highly prevalent condition, especially in obese children, and has been associated with increased risk for endothelial dysfunction and dislipidemia, which are precursors of atherosclerosis. Lipoprotein-associated phospholipase A2 (Lp-PLA2) is recognized as an independent risk factor for cardiovascular risk and atheromatous plaque activity. We hypothesized that Lp-PLA2 levels would be elevated in children with OSA, particularly among obese children who also manifest evidence of endothelial dysfunction.One hundred sixty children (mean age 7.1±2.3 years), either nonobese with (n=40) and without OSA (n=40) or obese with (n=40) and without OSA (n=40) underwent overnight polysomnographic and postocclusive reperfusion evaluation and a fasting blood draw the morning after the sleep study. In addition to lipid profile, Lp-PLA2 plasma activity was assessed using a commercial kit. Obese children and OSA children had significantly elevated plasma Lp-PLA2 activity levels compared to controls. Furthermore, when both obesity and OSA were concurrently present or when endothelial function was present, Lp-PLA2 activity was higher. Treatment of OSA by adenotonsillectomy resulted in reductions of Lp-PLA2 activity (n=37; P<0.001).Lp-PLA2 plasma activity is increased in pediatric OSA and obesity, particularly when endothelial dysfunction is present, and exhibits decreases on OSA treatment. The short-term and long-term significance of these findings in relation to cardiovascular risk remain undefined.

SUBMITTER: Kheirandish-Gozal L 

PROVIDER: S-EPMC5523777 | biostudies-other | 2017 Feb

REPOSITORIES: biostudies-other

Similar Datasets

| S-EPMC7883455 | biostudies-literature
| S-EPMC3029939 | biostudies-literature
| S-EPMC9896631 | biostudies-literature
| S-EPMC5861541 | biostudies-literature
| S-EPMC6973114 | biostudies-literature
| S-EPMC3616686 | biostudies-literature
2012-09-01 | E-GEOD-38792 | biostudies-arrayexpress
| S-EPMC3296460 | biostudies-literature
2012-09-01 | GSE38792 | GEO
| S-EPMC3726633 | biostudies-literature