Targeting of VEGF-dependent transendothelial migration of cancer cells by bevacizumab.
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ABSTRACT:
SUBMITTER: Prager GW
PROVIDER: S-EPMC5527896 | biostudies-other | 2010 Apr
REPOSITORIES: biostudies-other
Publications
Targeting of VEGF-dependent transendothelial migration of cancer cells by bevacizumab.
Prager Gerald W GW Lackner Eva-Maria EM Krauth Maria-Theresa MT Unseld Matthias M Poettler Marina M Laffer Sylvia S Cerny-Reiterer Sabine S Lamm Wolfgang W Kornek Gabriela V GV Binder Bernd R BR Zielinski Christoph C CC Valent Peter P
Molecular oncology 20100107 2
Cancer progression is often associated with the formation of malignant effusions. Vascular endothelial growth factor (VEGF) is a major regulator of vascular permeability and has been implicated as mediator of tumor progression. We examined the production and secretion of VEGF(165) in various primary cancer cells derived from malignant effusions, and the role of exogenous VEGF(165) as a mediator of effusion formation. VEGF(165) was constantly secreted by all cultured tumor cells in an mTOR-depend ...[more]
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