Ontology highlight
ABSTRACT:
SUBMITTER: Reymond N
PROVIDER: S-EPMC3494849 | biostudies-other | 2012 Nov
REPOSITORIES: biostudies-other
Reymond Nicolas N Im Jae Hong JH Garg Ritu R Vega Francisco M FM Borda d'Agua Barbara B Riou Philippe P Cox Susan S Valderrama Ferran F Muschel Ruth J RJ Ridley Anne J AJ
The Journal of cell biology 20121101 4
Cancer cells interact with endothelial cells during the process of metastatic spreading. Here, we use a small interfering RNA screen targeting Rho GTPases in cancer cells to identify Cdc42 as a critical regulator of cancer cell-endothelial cell interactions and transendothelial migration. We find that Cdc42 regulates β1 integrin expression at the transcriptional level via the transcription factor serum response factor (SRF). β1 integrin is the main target for Cdc42-mediating interaction of cance ...[more]