Ontology highlight
ABSTRACT:
SUBMITTER: Yokoo T
PROVIDER: S-EPMC552897 | biostudies-other | 2005 Mar
REPOSITORIES: biostudies-other
Yokoo Takashi T Ohashi Toya T Shen Jin Song JS Sakurai Ken K Miyazaki Yoichi Y Utsunomiya Yasunori Y Takahashi Masanori M Terada Yoshio Y Eto Yoshikatsu Y Kawamura Tetsuya T Osumi Noriko N Hosoya Tatsuo T
Proceedings of the National Academy of Sciences of the United States of America 20050222 9
The use of stem cells has enabled the successful generation of simple organs. However, anatomically complicated organs such as the kidney have proven more refractory to stem-cell-based regenerative techniques. Given the limits of allogenic organ transplantation, an ultimate therapeutic solution is to establish self-organs from autologous stem cells and transplant them as syngrafts back into donor patients. To this end, we have striven to establish an in vitro organ factory to build up complex or ...[more]