Ontology highlight
ABSTRACT:
SUBMITTER: Villeneuve J
PROVIDER: S-EPMC5529663 | biostudies-other | 2017
REPOSITORIES: biostudies-other
Villeneuve Julien J Desmoulière Alexis A Dewitte Antoine A Bordeau Nelly N Costet Pierre P Bassaganyas Laia L Fricain Jean-Christophe JC Ripoche Jean J Lepreux Sébastien S
Mediators of inflammation 20170712
Granulomatous inflammation is a distinctive form of chronic inflammation in which predominant cells include macrophages, epithelioid cells, and multinucleated giant cells. Mechanisms regulating granulomatous inflammation remain ill-understood. CD154, the ligand of CD40, is a key mediator of inflammation. CD154 confers a proinflammatory phenotype to macrophages and controls several macrophagic functions. Here, we studied the contribution of CD154 in a mouse model of toxic liver injury with carbon ...[more]