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VARIABLE RATE IV INFUSION OF MORPHINE AND HAEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND TRACHEAL INTUBATION.

ABSTRACT: Haemodynamic response to laryngoscopy and tracheal intubation was studied in two groups of 45 patients each. Group I patients received variable rate infusion of morphine for 30 minutes followed by intravenous (IV) bolus dose of diazepam. Group II patients received intramuscular morphine as preanaesthetic premedication and preinduction IV bolus dose of diazepam. The method of induction of GA was same in both the groups. Systolic and diastolic blood pressure (SBP and DBP) mean arterial pressure and pulse-rate were recorded at intubation and at different time intervals upto 10 minutes after intubation. In group I patients, there was no statistically significant increase in pulse-rate and SBP following intubation but transient significant increase in DBP. In group II patients, there was statistically significant increase in pulse-rate, SBP and DBP upto 3 minutes post-intubation. Thus IV infusion of morphine in combination with IV bolus dose of diazepam proved more effective in attenuating haemodynamic response to tracheal intubation.

SUBMITTER: Velankar PM

PROVIDER: S-EPMC5529727 | biostudies-other | 1994 Jul

REPOSITORIES: biostudies-other

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Project description:BACKGROUND:Phenylephrine is the most commonly used vasopressor for prophylaxis against maternal hypotension during cesarean delivery; however, the best regimen for its administration is not well established. Although variable infusion protocols had been suggested for phenylephrine infusion, evidence-based evaluation of variable infusion regimens are lacking. The aim of this work is to compare variable infusion, fixed on-and-off infusion, and intermittent boluses of phenylephrine for prophylaxis against maternal hypotension during cesarean delivery. METHODS:A randomized controlled study was conducted, including full-term pregnant women scheduled for elective cesarean delivery. Participants were divided into three groups which received phenylephrine by either intermittent boluses (1.5 mcg/Kg phenylephrine), fixed on-and-off infusion (with a dose of 0.75 mcg/Kg/min), or variable infusion (with a starting dose of 0.75 mcg/Kg/min). The three groups were compared with regard to frequency of: maternal hypotension (primary outcome), second episode hypotension, reactive hypertension, and bradycardia. Other outcomes included heart rate, systolic blood pressure, physician interventions, and neonatal outcomes. RESULTS:Two-hundred and seventeen mothers were available for final analysis. The 2 infusion groups showed less incidence of maternal hypotension {26/70 (37%), 22/71 (31%), and (51/76 (67%)} and higher incidence of reactive hypertension compared to the intermittent boluses group without significant differences between the two former groups. The number of physician interventions was highest in the variable infusion group compared to the other two groups. The intermittent boluses group showed lower systolic blood pressure and higher heart rate compared to the two infusion groups; whilst the two later groups were comparable. CONCLUSION:Both phenylephrine infusion regimens equally prevented maternal hypotension during cesarean delivery compared to intermittent boluses regimen. Due to higher number of physician interventions in the variable infusion regimen, the current recommendations which favor this regimen over fixed infusion regimen might need re-evaluation.

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VARIABLE RATE IV INFUSION OF MORPHINE AND HAEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND TRACHEAL INTUBATION.

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