Ontology highlight
ABSTRACT:
SUBMITTER: Zou L
PROVIDER: S-EPMC5538294 | biostudies-other | 2017 Aug
REPOSITORIES: biostudies-other
Zou Lili L Lu Jun J Wang Jun J Ren Xiaoyuan X Zhang Lanlan L Gao Yu Y Rottenberg Martin E ME Holmgren Arne A
EMBO molecular medicine 20170801 8
Multidrug-resistant (MDR) Gram-negative bacteria account for a majority of fatal infections, and development of new antibiotic principles and drugs is therefore of outstanding importance. Here, we report that five most clinically difficult-to-treat MDR Gram-negative bacteria are highly sensitive to a synergistic combination of silver and ebselen. In contrast, silver has no synergistic toxicity with ebselen on mammalian cells. The silver and ebselen combination causes a rapid depletion of glutath ...[more]