Ontology highlight
ABSTRACT:
SUBMITTER: David JP
PROVIDER: S-EPMC554807 | biostudies-other | 2005 Mar
REPOSITORIES: biostudies-other
David Jean-Philippe JP Strode Clare C Vontas John J Nikou Dimitra D Vaughan Ashley A Pignatelli Patricia M PM Louis Christos C Hemingway Janet J Ranson Hilary H
Proceedings of the National Academy of Sciences of the United States of America 20050307 11
Metabolic pathways play an important role in insecticide resistance, but the full spectra of the genes involved in resistance has not been established. We constructed a microarray containing unique fragments from 230 Anopheles gambiae genes putatively involved in insecticide metabolism [cytochrome P450s (P450s), GSTs, and carboxylesterases and redox genes, partners of the P450 oxidative metabolic complex, and various controls]. We used this detox chip to monitor the expression of the detoxifying ...[more]