Ontology highlight
ABSTRACT:
SUBMITTER: Shiba S
PROVIDER: S-EPMC5548899 | biostudies-other | 2017 Aug
REPOSITORIES: biostudies-other
Shiba Sachiko S Ikeda Kazuhiro K Horie-Inoue Kuniko K Nakayama Akitoshi A Tanaka Tomoaki T Inoue Satoshi S
Scientific reports 20170808 1
Mitochondria are essential organelles to efficiently produce ATP by ATP-synthase, which uses a proton-gradient generated by respiratory chain complexes. We previously demonstrated that COX7RP/COX7A2L/SCAF1 is a key molecule that promotes respiratory supercomplex assembly and regulates energy generation. The contribution of COX7RP to metabolic homeostasis, however, remains to be clarified. In the present study, we showed a metabolic phenotype of Cox7rp knockout (Cox7rpKO) mice, which exhibit lowe ...[more]