Enpp1 is an anti-aging factor that regulates Klotho under phosphate overload conditions.
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ABSTRACT:
SUBMITTER: Watanabe R
PROVIDER: S-EPMC5552841 | biostudies-other | 2017 Aug
REPOSITORIES: biostudies-other
Publications
Enpp1 is an anti-aging factor that regulates Klotho under phosphate overload conditions.
Watanabe Ryuichi R Fujita Nobuyuki N Sato Yuiko Y Kobayashi Tami T Morita Mayu M Oike Takatsugu T Miyamoto Kana K Kuro-O Makoto M Michigami Toshimi T Fukumoto Seiji S Tsuji Takashi T Toyama Yoshiaki Y Nakamura Masaya M Matsumoto Morio M Miyamoto Takeshi T
Scientific reports 20170810 1
Control of phosphate metabolism is crucial to regulate aging in mammals. Klotho is a well-known anti-aging factor that regulates phosphate metabolism: mice mutant or deficient in Klotho exhibit phenotypes resembling human aging. Here we show that ectonucleotide pyrophosphatase/phosphodiesterase 1 (Enpp1) is required for Klotho expression under phosphate overload conditions. Loss-of-function Enpp1 <sup>ttw/ttw</sup> mice under phosphate overload conditions exhibited phenotypes resembling human ag ...[more]
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