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The Mitochondrial Ca2+ Uniporter: Structure, Function, and Pharmacology.


ABSTRACT: Mitochondrial Ca2+ uptake is crucial for an array of cellular functions while an imbalance can elicit cell death. In this chapter, we briefly reviewed the various modes of mitochondrial Ca2+ uptake and our current understanding of mitochondrial Ca2+ homeostasis in regards to cell physiology and pathophysiology. Further, this chapter focuses on the molecular identities, intracellular regulators as well as the pharmacology of mitochondrial Ca2+ uniporter complex.

SUBMITTER: Mishra J 

PROVIDER: S-EPMC5554456 | biostudies-other | 2017

REPOSITORIES: biostudies-other

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