Ontology highlight
ABSTRACT:
SUBMITTER: Matsushima Y
PROVIDER: S-EPMC5559520 | biostudies-other | 2017 Aug
REPOSITORIES: biostudies-other
Matsushima Yuichi Y Hirofuji Yuta Y Aihara Masamune M Yue Song S Uchiumi Takeshi T Kaguni Laurie S LS Kang Dongchon D
Scientific reports 20170816 1
ClpXP is the major protease in the mitochondrial matrix in eukaryotes, and is well conserved among species. ClpXP is composed of a proteolytic subunit, ClpP, and a chaperone-like subunit, ClpX. Although it has been proposed that ClpXP is required for the mitochondrial unfolded protein response, additional roles for ClpXP in mitochondrial biogenesis are unclear. Here, we found that Drosophila leucine-rich pentatricopeptide repeat domain-containing protein 1 (DmLRPPRC1) is a specific substrate of ...[more]