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Necrotizing Pancreatitis: Current Management and Therapies.


ABSTRACT: Acute necrotizing pancreatitis accounts for 10% of acute pancreatitis (AP) cases and is associated with a higher mortality and morbidity. Necrosis within the first 4 weeks of disease onset is defined as an acute necrotic collection (ANC), while walled off pancreatic necrosis (WOPN) develops after 4 weeks of disease onset. An infected or symptomatic WOPN requires drainage. The management of pancreatic necrosis has shifted away from open necrosectomy, as it is associated with a high morbidity, to less invasive techniques. In this review, we summarize the current management and therapies for acute necrotizing pancreatitis.

SUBMITTER: Boumitri C 

PROVIDER: S-EPMC5565044 | biostudies-other | 2017 Jul

REPOSITORIES: biostudies-other

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Necrotizing Pancreatitis: Current Management and Therapies.

Boumitri Christine C   Brown Elizabeth E   Kahaleh Michel M  

Clinical endoscopy 20170516 4


Acute necrotizing pancreatitis accounts for 10% of acute pancreatitis (AP) cases and is associated with a higher mortality and morbidity. Necrosis within the first 4 weeks of disease onset is defined as an acute necrotic collection (ANC), while walled off pancreatic necrosis (WOPN) develops after 4 weeks of disease onset. An infected or symptomatic WOPN requires drainage. The management of pancreatic necrosis has shifted away from open necrosectomy, as it is associated with a high morbidity, to  ...[more]

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