Ontology highlight
ABSTRACT:
SUBMITTER: Tao W
PROVIDER: S-EPMC5572660 | biostudies-other | 2017 May
REPOSITORIES: biostudies-other
Tao Wenqian W Hurst Brett L BL Shakya Akhilesh Kumar AK Uddin Md Jasim MJ Ingrole Rohan S J RS Hernandez-Sanabria Mayra M Arya Ravi P RP Bimler Lynn L Paust Silke S Tarbet E Bart EB Tarbet E Bart EB Gill Harvinder Singh HS
Antiviral research 20170202
The extracellular domain of influenza A ion channel membrane matrix protein 2 (M2e) is considered to be a potential candidate to develop a universal influenza A vaccine. However poor immunogenicity of M2e presents a significant roadblock. We have developed a vaccine formulation comprising of the consensus M2e peptide conjugated to gold nanoparticles (AuNPs) with CpG as a soluble adjuvant (AuNP-M2e + sCpG). We demonstrate that intranasal delivery of AuNP-M2e + sCpG in mice induces lung B cell act ...[more]