Ontology highlight
ABSTRACT:
SUBMITTER: de Vink PJ
PROVIDER: S-EPMC5575475 | biostudies-other | 2017 Jul
REPOSITORIES: biostudies-other
Angewandte Chemie (International ed. in English) 20170629 31
Interactions between proteins frequently involve recognition sequences based on multivalent binding events. Dimeric 14-3-3 adapter proteins are a prominent example and typically bind partner proteins in a phosphorylation-dependent mono- or bivalent manner. Herein we describe the development of a cucurbit[8]uril (Q8)-based supramolecular system, which in conjunction with the 14-3-3 protein dimer acts as a binary and bivalent protein assembly platform. We fused the phenylalanine-glycine-glycine (F ...[more]