Ontology highlight
ABSTRACT:
SUBMITTER: Plooster M
PROVIDER: S-EPMC5576901 | biostudies-other | 2017 Sep
REPOSITORIES: biostudies-other
Plooster Melissa M Menon Shalini S Winkle Cortney C CC Urbina Fabio L FL Monkiewicz Caroline C Phend Kristen D KD Weinberg Richard J RJ Gupton Stephanie L SL
Molecular biology of the cell 20170712 18
Extracellular netrin-1 and its receptor deleted in colorectal cancer (DCC) promote axon branching in developing cortical neurons. Netrin-dependent morphogenesis is preceded by multimerization of DCC, activation of FAK and Src family kinases, and increases in exocytic vesicle fusion, yet how these occurrences are linked is unknown. Here we demonstrate that <u>tri</u>partite <u>m</u>otif protein 9 (TRIM9)-dependent ubiquitination of DCC blocks the interaction with and phosphorylation of FAK. Upon ...[more]