Ontology highlight
ABSTRACT:
SUBMITTER: Di Pietro C
PROVIDER: S-EPMC5589856 | biostudies-other | 2017 Sep
REPOSITORIES: biostudies-other
Di Pietro Caterina C Zhang Ping-Xia PX O'Rourke Timothy K TK Murray Thomas S TS Wang Lin L Britto Clemente J CJ Koff Jonathan L JL Krause Diane S DS Egan Marie E ME Bruscia Emanuela M EM
Scientific reports 20170907 1
Macrophages (MΦs) with mutations in cystic fibrosis transmembrane conductance regulator (CFTR) have blunted induction of PI3K/AKT signaling in response to TLR4 activation, leading to hyperinflammation, a hallmark of cystic fibrosis (CF) disease. Here, we show that Ezrin links CFTR and TLR4 signaling, and is necessary for PI3K/AKT signaling induction in response to MΦ activation. Because PI3K/AKT signaling is critical for immune regulation, Ezrin-deficient MΦs are hyperinflammatory and have impai ...[more]