Ontology highlight
ABSTRACT:
SUBMITTER: Arbiser JL
PROVIDER: S-EPMC5593857 | biostudies-other | 2017 Sep
REPOSITORIES: biostudies-other
Arbiser Jack L JL Nowak Ron R Michaels Kellie K Skabytska Yuliya Y Biedermann Tilo T Lewis Monica J MJ Bonner Michael Y MY Rao Shikha S Gilbert Linda C LC Yusuf Nabiha N Karlsson Isabella I Fritz Yi Y Ward Nicole L NL
Scientific reports 20170911 1
Psoriasis is a chronic inflammatory skin disease affecting 2.5-6 million patients in the United States. The cause of psoriasis remains unknown. Previous human and animal studies suggest that patients with a susceptible genetic background and some stimulus, such as barrier disruption, leads to a coordinated signaling events involving cytokines between keratinocytes, endothelial cells, T cells, macrophages and dendritic cells. Ceramides are endogenous skin lipids essential for maintaining skin bar ...[more]