Ontology highlight
ABSTRACT:
SUBMITTER: Kim M
PROVIDER: S-EPMC5596211 | biostudies-other | 2017 Sep
REPOSITORIES: biostudies-other
Kim M M Jang K K Miller P P Picon-Ruiz M M Yeasky T M TM El-Ashry D D Slingerland J M JM
Oncogene 20170515 36
Cancer stem cells (CSC) appear to have increased metastatic potential, but mechanisms underlying this are poorly defined. Here we show that VEGFA induction of Sox2 promotes EMT and tumor metastasis. In breast lines and primary cancer culture, VEGFA rapidly upregulates SOX2 expression, leading to SNAI2 induction, EMT, increased invasion and metastasis. We show Sox2 downregulates miR-452, which acts as a novel metastasis suppressor to directly target the SNAI2 3'-untranslated region (3'-UTR). VEGF ...[more]