Ontology highlight
ABSTRACT:
SUBMITTER: Terrillion CE
PROVIDER: S-EPMC5603806 | biostudies-other | 2017 Oct
REPOSITORIES: biostudies-other
Terrillion Chantelle E CE Abazyan Bagrat B Yang Zhongxi Z Crawford Joshua J Shevelkin Alexey V AV Jouroukhin Yan Y Yoo Ki Hyun KH Cho Chang Hoon CH Roychaudhuri Robin R Snyder Solomon H SH Jang Mi-Hyeon MH Pletnikov Mikhail V MV
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20170620 11
The functional role of genetic variants in glia in the pathogenesis of psychiatric disorders remains poorly studied. Disrupted-In-Schizophrenia 1 (DISC1), a genetic risk factor implicated in major mental disorders, has been implicated in regulation of astrocyte functions. As both astrocytes and DISC1 influence adult neurogenesis in the dentate gyrus (DG) of the hippocampus, we hypothesized that selective expression of dominant-negative C-terminus-truncated human DISC1 (mutant DISC1) in astrocyte ...[more]