Ontology highlight
ABSTRACT:
SUBMITTER: Nikolayevskiy H
PROVIDER: S-EPMC5603897 | biostudies-other | 2017 Jul
REPOSITORIES: biostudies-other
Chemical science 20170504 7
Ocimicide A<sub>1</sub> (<b>1</b>) and the semisynthetic derivative ocimicide A<sub>2</sub> (<b>2</b>) are highly potent antimalarial agents efficacious against chloroquine-sensitive and -resistant <i>Plasmodium falciparum</i> strains with IC<sub>50</sub> values in the nanomolar and picomolar range, respectively. Members of this family have demonstrated radical cure in rhesus monkeys, without detectable toxicity, but their structure-function relationships and mechanism of action are unknown. Her ...[more]