Dataset Information

Interaction effects of GIT1 and DRD4 gene variants on continuous performance test variables in patients with ADHD.

ABSTRACT: The G protein-coupled receptor kinase interacting protein 1 gene (GIT1) has been proposed to be a risk gene for attention deficit hyperactivity disorder (ADHD), and it regulates the endocytosis of G protein-coupled receptors like dopamine receptors. The purpose of this study was to investigate the interaction effects of GIT1 and dopamine receptor D4 (DRD4) gene variants on variables of the continuous performance test (CPT).This study recruited 255 ADHD patients and 98 healthy controls (HC) who underwent CPT and genetic analyses. The genotypes were classified into two groups (the C/C and C/T genotype groups for GIT1, 4R homozygotes and others for DRD4) and the genotype × genotype effects were examined using hierarchical multivariable linear regression analyses.There were significant GIT1 × DRD4 effects for commission errors on the CPT in the ADHD group (p = .006). In contrast, there were no significant GIT1 × DRD4 effects on any CPT variables in the HC.The present findings demonstrated that there were significant interaction effects of the GIT1 and DRD4 gene variants on impulsivity in ADHD. Replication studies with larger sample sizes that include patients from various ethnic backgrounds are warranted to confirm these findings.

SUBMITTER: Kim H

PROVIDER: S-EPMC5607549 | biostudies-other | 2017 Sep

REPOSITORIES: biostudies-other

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Interaction effects of <i>GIT1</i> and <i>DRD4</i> gene variants on continuous performance test variables in patients with ADHD.

Kim Hyojin H Kim Johanna Inhyang JI Kim Haebin H Kim Jae-Won JW Kim Bung-Nyun BN

Brain and behavior 20170801 9

<h4>Introduction</h4>The G protein-coupled receptor kinase interacting protein 1 gene (<i>GIT1</i>) has been proposed to be a risk gene for attention deficit hyperactivity disorder (ADHD), and it regulates the endocytosis of G protein-coupled receptors like dopamine receptors. The purpose of this study was to investigate the interaction effects of <i>GIT1</i> and dopamine receptor D4 (<i>DRD4</i>) gene variants on variables of the continuous performance test (CPT).<h4>Methods</h4>This study recr ...[more]

PMID: 28948080

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Project description:BackgroundOne of the major challenges in mental medical care is finding out new instruments for an accurate and objective evaluation of the attention deficit hyperactivity disorder (ADHD). Early ADHD identification, severity assessment, and prompt treatment are essential to avoid the negative effects associated with this mental condition.ObjectiveThe aim of our study was to develop a novel ADHD assessment instrument based on Microsoft Kinect, which identifies ADHD cardinal symptoms in order to provide a more accurate evaluation.MethodsA group of 30 children, aged 8-12 years (10.3 [SD 1.4]; male 70% [21/30]), who were referred to the Child and Adolescent Psychiatry Unit of the Department of Psychiatry at Fundación Jiménez Díaz Hospital (Madrid, Spain), were included in this study. Children were required to meet the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria of ADHD diagnosis. One of the parents or guardians of the children filled the Spanish version of the Strengths and Weaknesses of ADHD Symptoms and Normal Behavior (SWAN) rating scale used in clinical practice. Each child conducted a Kinect-based continuous performance test (CPT) in which the reaction time (RT), the commission errors, and the time required to complete the reaction (CT) were calculated. The correlations of the 3 predictors, obtained using Kinect methodology, with respect to the scores of the SWAN scale were calculated.ResultsThe RT achieved a correlation of -.11, -.29, and -.37 with respect to the inattention, hyperactivity, and impulsivity factors of the SWAN scale. The correlations of the commission error with respect to these 3 factors were -.03, .01, and .24, respectively.ConclusionsOur findings show a relation between the Microsoft Kinect-based version of the CPT and ADHD symptomatology assessed through parental report. Results point out the importance of future research on the development of objective measures for the diagnosis of ADHD among children and adolescents.

Dataset Information

Interaction effects of GIT1 and DRD4 gene variants on continuous performance test variables in patients with ADHD.

Publications

Interaction effects of <i>GIT1</i> and <i>DRD4</i> gene variants on continuous performance test variables in patients with ADHD.

Similar Datasets

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