Ontology highlight
ABSTRACT:
SUBMITTER: Karra AS
PROVIDER: S-EPMC5608137 | biostudies-other | 2017 May
REPOSITORIES: biostudies-other
Karra Aroon S AS Stippec Steve S Cobb Melanie H MH
Journal of visualized experiments : JoVE 20170526 123
Protein kinases are able to govern large-scale cellular changes in response to complex arrays of stimuli, and much effort has been directed at uncovering allosteric details of their regulation. Kinases comprise signaling networks whose defects are often hallmarks of multiple forms of cancer and related diseases, making an assay platform amenable to manipulation of upstream regulatory factors and validation of reaction requirements critical in the search for improved therapeutics. Here, we descri ...[more]