Ontology highlight
ABSTRACT:
SUBMITTER: Campfield BT
PROVIDER: S-EPMC5609702 | biostudies-other | 2017 Sep
REPOSITORIES: biostudies-other
Campfield Brian T BT Eddens Taylor T Henkel Matthew M Majewski Martin M Horne William W Chaly Yury Y Gaffen Sarah L SL Hirsch Raphael R Kolls Jay K JK
Immunology and cell biology 20170405 8
Follistatin-like protein 1 (FSTL-1) possesses several newly identified roles in mammalian biology, including interleukin (IL)-17-driven inflammation, though the mechanism underlying FSTL-1 influence on IL-17-mediated cytokine production is unknown. Using parallel in vitro bone marrow stromal cell models of FSTL-1 suppression, we employed unbiased microarray analysis to identify FSTL-1-regulated genes and pathways that could influence IL-17-dependent production of IL-6 and granulocyte colony-stim ...[more]