Data on association between QRS duration on prehospital ECG and mortality in patients with confirmed STEMI.
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ABSTRACT:
SUBMITTER: Hansen R
PROVIDER: S-EPMC5609869 | biostudies-other | 2017 Dec
REPOSITORIES: biostudies-other
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Data on association between QRS duration on prehospital ECG and mortality in patients with confirmed STEMI.
Hansen Rikke R Frydland Martin M Møller-Helgestad Ole Kristian OK Lindholm Matias Greve MG Jensen Lisette Okkels LO Holmvang Lene L Ravn Hanne Berg HB Kjærgaard Jesper J Hassager Christian C Møller Jacob Eifer JE
Data in brief 20170905
<i>Data presented in this article relates to the research article entitled "</i>Association between QRS duration on prehospital ECG and mortality in patients with suspected STEMI" (Hansen et al., in press) [1]. Data on the prognostic effect of automatically recoded QRS duration on prehospital ECG and presence of classic left and right bundle branch block in 1777 consecutive patients with confirmed ST segment elevation AMI is presented. Multivariable analysis, suggested that QRS duration >111 ms, ...[more]
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Project description:The electrocardiographic QRS duration, a measure of ventricular depolarization and conduction, is associated with cardiovascular mortality. While single nucleotide polymorphisms (SNPs) associated with QRS duration have been identified at 22 loci in populations of European descent, the genetic architecture of QRS duration in non-European populations is largely unknown. We therefore performed a genome-wide association study (GWAS) meta-analysis of QRS duration in 13,031 African Americans from ten cohorts and a transethnic GWAS meta-analysis with additional results from populations of European descent. In the African American GWAS, a single genome-wide significant SNP association was identified (rs3922844, P?=?4?×?10-14) in intron 16 of SCN5A, a voltage-gated cardiac sodium channel gene. The QRS-prolonging rs3922844 C allele was also associated with decreased SCN5A RNA expression in human atrial tissue (P?=?1.1?×?10-4). High density genotyping revealed that the SCN5A association region in African Americans was confined to intron 16. Transethnic GWAS meta-analysis identified novel SNP associations on chromosome 18 in MYL12A (rs1662342, P?=?4.9?×?10-8) and chromosome 1 near CD1E and SPTA1 (rs7547997, P?=?7.9?×?10-9). The 22 QRS loci previously identified in populations of European descent were enriched for significant SNP associations with QRS duration in African Americans (P?=?9.9?×?10-7), and index SNP associations in or near SCN5A, SCN10A, CDKN1A, NFIA, HAND1, TBX5 and SETBP1 replicated in African Americans. In summary, rs3922844 was associated with QRS duration and SCN5A expression, two novel QRS loci were identified using transethnic meta-analysis, and a significant proportion of QRS-SNP associations discovered in populations of European descent were transferable to African Americans when adequate power was achieved.
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