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The Inter-rater Variability of Clinical Assessment in Post-anoxic Myoclonus.


ABSTRACT: Acute post-anoxic myoclonus (PAM) can be divided into an unfavorable (generalized/subcortical) and more favorable ((multi)focal/cortical) outcome group that could support prognostication in post-anoxic encephalopathy; however, the inter-rater variability of clinically assessing these PAM subtypes is unknown.We prospectively examined PAM patients using a standardized video protocol. Videos were rated by three neurologists who classified PAM phenotype (generalized/(multi)focal), stimulus sensitivity, localization (proximal/distal/both), and severity (Clinical Global Impression-Severity Scale (CGI-S) and Unified Myoclonus Rating Scale (UMRS)).Poor inter-rater agreement was found for phenotype and stimulus sensitivity (κ=-0.05), moderate agreement for localization (κ=0.46). Substantial agreement was obtained for the CGI-S (intraclass correlation coefficient (ICC)=0.64) and almost perfect agreement for the UMRS (ICC=0.82).Clinical assessment of PAM is not reproducible between physicians, and should therefore not be used for prognostication. PAM severity measured by the UMRS appears to be reliable; however, the relation between PAM severity and outcome is unknown.

SUBMITTER: van Zijl JC 

PROVIDER: S-EPMC5618111 | biostudies-other | 2017

REPOSITORIES: biostudies-other

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The Inter-rater Variability of Clinical Assessment in Post-anoxic Myoclonus.

van Zijl Jonathan C JC   Beudel Martijn M   Elting Jan-Willem J JJ   de Jong Bauke M BM   van der Naalt Joukje J   van den Bergh Walter M WM   Rossetti Andrea O AO   Tijssen Marina A J MAJ   Horn Janneke J  

Tremor and other hyperkinetic movements (New York, N.Y.) 20170713


<h4>Background</h4>Acute post-anoxic myoclonus (PAM) can be divided into an unfavorable (generalized/subcortical) and more favorable ((multi)focal/cortical) outcome group that could support prognostication in post-anoxic encephalopathy; however, the inter-rater variability of clinically assessing these PAM subtypes is unknown.<h4>Methods</h4>We prospectively examined PAM patients using a standardized video protocol. Videos were rated by three neurologists who classified PAM phenotype (generalize  ...[more]

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