Ontology highlight
ABSTRACT:
SUBMITTER: Araujo DFS
PROVIDER: S-EPMC5619769 | biostudies-other | 2017
REPOSITORIES: biostudies-other
Araújo Daline F S DFS Guerra Gerlane C B GCB Pintado Maria Manuela E MME Sousa Yasmim R F YRF Algieri Francesca F Rodriguez-Nogales Alba A Araújo Raimundo F RF Gálvez Julio J Queiroga Rita de Cássia R E RCRE Rodriguez-Cabezas Maria Elena ME
PloS one 20170928 9
This study evaluated the intestinal anti-inflammatory effects of goat whey in a mouse model of colitis induced by 2,4-dinitrobenzenesulfonic acid that resembles human IBD. At a concentration of 4 g/kg/day, the goat whey improved the symptoms of intestinal inflammation, namely by decreasing the disease activity index, colonic weight/length, and leukocyte infiltration. Moreover, goat whey inhibited NF-κB p65 and p38 MAPK signaling pathways and consequently down-regulated the gene expression of var ...[more]