Ontology highlight
ABSTRACT:
SUBMITTER: Fan J
PROVIDER: S-EPMC5623860 | biostudies-other | 2017 Oct
REPOSITORIES: biostudies-other
The EMBO journal 20170811 19
The exosome is a key RNA machine that functions in the degradation of unwanted RNAs. Here, we found that significant fractions of precursors and mature forms of mRNAs and long noncoding RNAs are degraded by the nuclear exosome in normal human cells. Exosome-mediated degradation of these RNAs requires its cofactor hMTR4. Significantly, hMTR4 plays a key role in specifically recruiting the exosome to its targets. Furthermore, we provide several lines of evidence indicating that hMTR4 executes this ...[more]