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Multi-functional bis(alkynyl)gold(iii) N?C complexes with distinct mechanochromic luminescence and electroluminescence properties.

ABSTRACT: A new class of donor-acceptor type luminescent bis(alkynyl)gold(iii) N?C complexes has been synthesized and characterized. These gold(iii) complexes not only exhibit high photoluminescence quantum yields of up to 0.81, but also interesting mechanochromic luminescence behaviors that are reversible. Upon grinding, a dramatic luminescence color change from green to red can be observed in solid samples of the gold(iii) complexes, and the mechanochromic luminescence can be readily tuned via a judicious selection of substituents on the pyridine ring. In addition, solution-processable OLEDs based on this class of complexes with EQE values of up to 4.0% have been realized, representing the first demonstration of bis(alkynyl)gold(iii) N?C complexes as emissive materials in solution-processable OLEDs.

SUBMITTER: Wong BY

PROVIDER: S-EPMC5632797 | biostudies-other | 2017 Oct

REPOSITORIES: biostudies-other

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Multi-functional bis(alkynyl)gold(iii) N⁁C complexes with distinct mechanochromic luminescence and electroluminescence properties.

Wong Ben Yiu-Wing BY Wong Hok-Lai HL Wong Yi-Chun YC Au Vonika Ka-Man VK Chan Mei-Yee MY Yam Vivian Wing-Wah VW

Chemical science 20170823 10

A new class of donor-acceptor type luminescent bis(alkynyl)gold(iii) N⁁C complexes has been synthesized and characterized. These gold(iii) complexes not only exhibit high photoluminescence quantum yields of up to 0.81, but also interesting mechanochromic luminescence behaviors that are reversible. Upon grinding, a dramatic luminescence color change from green to red can be observed in solid samples of the gold(iii) complexes, and the mechanochromic luminescence can be readily tuned <i>via</i> a ...[more]

PMID: 29147519

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Project description:BackgroundA number of cytostatic agents have been investigated for the ability to reactivate latent viral reservoirs, which is a major prerequisite for the eradication of HIV-1 infection. Two cytostatic bis(thiosemicarbazonate) gold(III) complexes (designated 1 and 2) were tested for this potential in the U1 latency model of HIV-1 infection.MethodsCell viability in the presence or absence of 1 and 2 was determined using a tetrazolium dye and evidence of reactivation was assessed by p24 antigen capture following exposure to a latency stimulant, phorbol myristate acetate (PMA) and or test compounds. The latency reactivation mechanism was explored by determining the effect of the complexes on protein kinase C (PKC), histone deacetylases (HDAC) and proinflammatory cytokine production.ResultsThe CC50 of the complexes in U1 cells were 0.53?±?0.12 ?M for 1 and 1.0?±?0.4 ?M for 2. In the absence of PMA and at non toxic concentrations of 0.2 and 0.5 ?M, 1 and 2 significantly (p???0.02) reactivated virus in U1 cells by 2.7 and 2.3 fold respectively. In comparison, a 2.6 fold increase (p?=?0.03) in viral reactivation was observed for hydroxyurea (HU), which was used as a cytostatic and latent HIV reactivation control. Viral reactivation was absent for the complexes during co-stimulation with PMA indicating the lack of an additive effect between the chemicals as well as an absence of inhibition of PMA induced HIV reactivation but for HU inhibition of the stimulant's activity was observed (p?=?0.01). Complex 1 and 2 activated PKC activity by up to 32% (p?<?0.05) but no significant inhibition of HDAC was observed. Increases in TNF-? levels suggested that the reactivation of virus by the complexes may have been due to contributions from the latter and the activation of PKC.ConclusionThe ethyl group structural difference between 1 and 2 seems to influence bioactivity with lower active concentrations of 1, suggesting that further structural modifications should improve specificity. The cytostatic effect of 1 and 2 and now HIV reactivation from a U1 latency model is consistent with that of the cytostatic agent, HU. These findings suggest that the complexes have a potential dual (cytostatic and reactivation) role in viral "activation/elimination".

Dataset Information

Multi-functional bis(alkynyl)gold(iii) N?C complexes with distinct mechanochromic luminescence and electroluminescence properties.

Publications

Multi-functional bis(alkynyl)gold(iii) N⁁C complexes with distinct mechanochromic luminescence and electroluminescence properties.

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