Ontology highlight
ABSTRACT:
SUBMITTER: Cosacak MI
PROVIDER: S-EPMC5636889 | biostudies-other | 2017 Oct
REPOSITORIES: biostudies-other
Cosacak Mehmet I MI Bhattarai Prabesh P Bocova Ledio L Dzewas Tim T Mashkaryan Violeta V Papadimitriou Christos C Brandt Kerstin K Hollak Heike H Antos Christopher L CL Kizil Caghan C
Scientific reports 20171011 1
Microtubule-associated TAU protein is a pathological hallmark in Alzheimer's disease (AD), where hyperphosphorylation of TAU generates neurofibrillary tangles. To investigate the effects of TAU in a regenerative adult vertebrate brain system, we generated a cre/lox-based transgenic model of zebrafish that chronically expresses human TAU<sup>P301L</sup>, which is a variant of human TAU protein that forms neurofibrillary tangles in mouse models and humans. Interestingly, we found that although chr ...[more]