Dataset Information

Similarity-Based Interference and the Acquisition of Adjunct Control.

ABSTRACT: Previous research on the acquisition of adjunct control has observed non-adultlike behavior for sentences like "John bumped Mary after tripping on the sidewalk." While adults only allow a subject control interpretation for these sentences (that John tripped on the sidewalk), preschool-aged children have been reported to allow a much wider range of interpretations. A number of different tasks have been used with the aim of identifying a grammatical source of children's errors. In this paper, we consider the role of extragrammatical factors. In two comprehension experiments, we demonstrate that error rates go up when the similarity increases between an antecedent and a linearly intervening noun phrase, first with similarity in gender, and next with similarity in number marking. This suggests that difficulties with adjunct control are to be explained (at least in part) by the sentence processing mechanisms that underlie similarity-based interference in adults.

SUBMITTER: Gerard J

PROVIDER: S-EPMC5651523 | biostudies-other | 2017

REPOSITORIES: biostudies-other

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Publications

Similarity-Based Interference and the Acquisition of Adjunct Control.

Gerard Juliana J Lidz Jeffrey J Zuckerman Shalom S Pinto Manuela M

Frontiers in psychology 20171018

Previous research on the acquisition of adjunct control has observed non-adultlike behavior for sentences like "<i>John bumped Mary after tripping on the sidewalk</i>." While adults only allow a subject control interpretation for these sentences (that John tripped on the sidewalk), preschool-aged children have been reported to allow a much wider range of interpretations. A number of different tasks have been used with the aim of identifying a grammatical source of children's errors. In this pape ...[more]

PMID: 29093692

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Project description:BackgroundCRISPR/Cas is a widespread adaptive immune system in prokaryotes. This system integrates short stretches of DNA derived from invading nucleic acids into genomic CRISPR loci, which function as memory of previously encountered invaders. In Escherichia coli, transcripts of these loci are cleaved into small RNAs and utilized by the Cascade complex to bind invader DNA, which is then likely degraded by Cas3 during CRISPR interference.ResultsWe describe how a CRISPR-activated E. coli K12 is cured from a high copy number plasmid under non-selective conditions in a CRISPR-mediated way. Cured clones integrated at least one up to five anti-plasmid spacers in genomic CRISPR loci. New spacers are integrated directly downstream of the leader sequence. The spacers are non-randomly selected to target protospacers with an AAG protospacer adjacent motif, which is located directly upstream of the protospacer. A co-occurrence of PAM deviations and CRISPR repeat mutations was observed, indicating that one nucleotide from the PAM is incorporated as the last nucleotide of the repeat during integration of a new spacer. When multiple spacers were integrated in a single clone, all spacer targeted the same strand of the plasmid, implying that CRISPR interference caused by the first integrated spacer directs subsequent spacer acquisition events in a strand specific manner.ConclusionsThe E. coli Type I-E CRISPR/Cas system provides resistance against bacteriophage infection, but also enables removal of residing plasmids. We established that there is a positive feedback loop between active spacers in a cluster--in our case the first acquired spacer--and spacers acquired thereafter, possibly through the use of specific DNA degradation products of the CRISPR interference machinery by the CRISPR adaptation machinery. This loop enables a rapid expansion of the spacer repertoire against an actively present DNA element that is already targeted, amplifying the CRISPR interference effect.

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Dataset Information

Similarity-Based Interference and the Acquisition of Adjunct Control.

Publications

Similarity-Based Interference and the Acquisition of Adjunct Control.

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