Ontology highlight
ABSTRACT:
SUBMITTER: Carne Trecesson S
PROVIDER: S-EPMC5654832 | biostudies-other | 2017 Oct
REPOSITORIES: biostudies-other
Nature communications 20171024 1
In tumours, accumulation of chemoresistant cells that express high levels of anti-apoptotic proteins such as BCL-X<sub>L</sub> is thought to result from the counter selection of sensitive, low expresser clones during progression and/or initial treatment. We herein show that BCL-X<sub>L</sub> expression is selectively advantageous to cancer cell populations even in the absence of pro-apoptotic pressure. In transformed human mammary epithelial cells BCL-X<sub>L</sub> favours full activation of sig ...[more]