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Research progress on circadian clock genes in common abdominal malignant tumors.


ABSTRACT: The circadian clock refers to the inherent biological rhythm of an organism, which, is accurately regulated by numerous clock genes. Studies in recent years have reported that the abnormal expression of clock genes is ubiquitous in common abdominal malignant tumors, including liver, colorectal, gastric and pancreatic cancer. In addition, the abnormal expression of certain clock genes is closely associated with clinical tumor parameters or patient prognosis. Studies in clock genes may expand the knowledge about the mechanism of occurrence and development of tumors, and may provide a new approach for tumor therapy. The present study summarizes the research progress in this field.

SUBMITTER: Yang SL 

PROVIDER: S-EPMC5661368 | biostudies-other | 2017 Nov

REPOSITORIES: biostudies-other

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Research progress on circadian clock genes in common abdominal malignant tumors.

Yang Sheng-Li SL   Ren Quan-Guang QG   Wen Lu L   Hu Jian-Li JL   Wang Heng-Yi HY  

Oncology letters 20170831 5


The circadian clock refers to the inherent biological rhythm of an organism, which, is accurately regulated by numerous clock genes. Studies in recent years have reported that the abnormal expression of clock genes is ubiquitous in common abdominal malignant tumors, including liver, colorectal, gastric and pancreatic cancer. In addition, the abnormal expression of certain clock genes is closely associated with clinical tumor parameters or patient prognosis. Studies in clock genes may expand the  ...[more]

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